To assess the global capacity for early detection of zoonotic disease spillovers — the pathway by which animal viruses cross into humans. Current systems cover <1% of spillover events before epidemic scale, leaving the vast majority undetected until human disease clusters emerge.

Synthesis of PREDICT final report spillover assessments across 34 countries with 10,500+ novel viruses detected. Analysis of detection lag from retrospective spillover timing studies. Institutional capacity assessment using WHO IHR indicators. Financing gap analysis comparing $900M-1.2B current spending against $10-15B estimated need.